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Effects of macrolide antibiotics on barbiturate sleeping time in mice

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  • Pharmacology, Toxicology
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Summary

Triacetyloleandomycin and josamycin, when administered to inbred Balb/c mice orally twice daily at a dose of 12.5 or 25 mg per kg over 3 days, were found to increase barbiturate sleeping time significantly. In contrast, erythromycin ethylsuccinate, erythromycin propionate, midecamycin and spiramycin were devoid of any such activity under the same conditions.

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Authors and Affiliations

  1. Laboratoire de Pharmacologie, Faculté de Médecine Alexis Carrel, rue G. Paradin, F-69008, Lyon, France

    J. Descotes & J. Cl. Evreux

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  1. J. Descotes
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  2. J. Cl. Evreux
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Descotes, J., Evreux, J.C. Effects of macrolide antibiotics on barbiturate sleeping time in mice. Experientia 39, 1389–1390 (1983). https://doi.org/10.1007/BF01990119

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  • DOI: https://doi.org/10.1007/BF01990119

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