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Structural alterations in rat kidney proximal tubules perfused with fresh autologous serum

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  • Anatomy, Histology, Histochemistry
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Summary

Two min of intraluminal perfusion of the rat proximal tubules with autologous serum induced marked ultrastructural alterations including extensive cytoplasmic vesiculation due to swelling of rough endoplasmic reticulum cisternae and occasional extrusion of nuclei and cytoplasm into the lumen. Within 4 min pronounced vesiculation of mitochondria was observed. These findings are consistent with the notion that serum-induced inhibition of proximal tubular fluid absorption is due to cell lysis, presumably mediated by complement activation.

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References

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Author notes

  1. K. Sato

    Present address: Department of Dermatology, University of Iowa College of Medicine, 52242, Iowa City, Iowa, USA

Authors and Affiliations

  1. Department of Dermatology, University of Iowa College of Medicine, 52242, Iowa City, Iowa, USA

    C. J. Bentzel

  2. Department of Medicine, State University of New York at Buffalo, VA Medical Center, 14214, Buffalo, New York, USA

    K. Sato & C. J. Bentzel

Authors
  1. K. Sato
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  2. C. J. Bentzel
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Additional information

Acknowledgment. This study was supported by NIH grants AM16258, AM27857, a New York Health Council grant, and a Veterans Administration Research grant.

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Sato, K., Bentzel, C.J. Structural alterations in rat kidney proximal tubules perfused with fresh autologous serum. Experientia 39, 394–396 (1983). https://doi.org/10.1007/BF01963143

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  • DOI: https://doi.org/10.1007/BF01963143

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