Skip to main content
SpringerLink
Log in

Predominant expression of σ and ε globin genes in human leukemia K-562(S6) variant cell line

  • Short Communications
  • Cellular Biology
  • Published:
Experientia Aims and scope Submit manuscript

Summary

In the human leukemia K-562(S6) cell line (a) the accumulation ofa-globin chains is low or absent, (b) ζ-globin gene expression is correlated with expression of ε-chains and (c) the genes responsible for the terminal cell division are not operated within 8–12 cell cycles, while K-562 (S6) cells are fully induced to erythroid differentiation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Lozzio, C. B., Lozzio, B. B., Machado, E. A., Fuhr, J. E., Loiz S. V., and Bamberger, E. G., Nature281 (1979) 709.

    Article  CAS  PubMed  Google Scholar 

  2. Rutherford, T. R., Clegg, J. B., and Weatherall, D. J., Nature280 (1979) 164.

    Article  CAS  PubMed  Google Scholar 

  3. Benz, E. J., Murnane, M. J., Tonkonow, B. L., Borman, B. W., Mazur, E. M., Cavallesco, C., Jenko, T., Snyder, E. L., Forget, B. G., and Hoffman, R., Proc. natl Acad. Sci. USA77 (1980) 3509.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Cioè, L., McNab, A., Hubbell, H. R., Meo, P., Curtiss, P., and Rovera, G., Cancer Res.41 (1981) 237.

    PubMed  Google Scholar 

  5. Rutherford, T. R., Clegg, J. B., Higgs, D. R., Jones, R. W., Thompson, J., and Weatherall, D. J., Proc. natl Acad. Sci. USA79 (1981) 348.

    Article  Google Scholar 

  6. Weatherall, D. J., and Clegg, J. B., The Thalassemia Syndromes. Blackwell Scientific Publications, Oxford 1981.

    Google Scholar 

  7. Wood, W. G., Clegg, J. B., and Weatherall, D. J., in: Progress in Hematology, vol. 10, p. 43 Ed. B. Brown. Grune & Stratton, New York 1977.

    Google Scholar 

  8. Fantoni, A., Gambari, R., and Farace, M.G., Blood57 (1981) 623.

    Article  CAS  PubMed  Google Scholar 

  9. Huens, F. R., Flynn F. V., Butler, E. A., and Beaver, G. H., Nature189 (1961) 496.

    Article  Google Scholar 

  10. Pootrakul, S., Wasi, P., and Na-Nakorn, S., Ann. Hum. Genet.30 (1967) 283.

    Article  Google Scholar 

  11. Testa, U., Vainchenker, W., Beuzard, Y., Rouyer-Fessard, P., Guerrasio, A., Titeux, M., Lapotre, P., Bouguet, J., Breton-Gorius, J., and Rosa, J., Eur. J. Biochem.121 (1982) 649.

    Article  CAS  PubMed  Google Scholar 

  12. Fibach, E., Gambari, R., Shaw, P. A., Maniatis G. M., Reuben, R. C., Sassa, S., Rifkind, R. A., Marks, P. A., Proc. natl Acad. Sci. USA76 (1979) 1906.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Ham, R. G., and McKeehan, W. L., in: Methods in Enzymology, vol. 58, p. 44. Eds. W. B. Jacoby and I. M. Pastan, Academic Press Inc., New York 1979.

    Google Scholar 

  14. Gambari, R., Rachellà, G., Tripodi, M., Fantoni, A., and Farace, M. G., in preparation.

Download references

Author information

Authors and Affiliations

  1. Istituto di Biologia Generale, Università di Roma, Roma, Italy

    R. Gambari, G. Raschellà, R. Biagini, M. Tripodi, M. G. Farace, A. Romeo & A. Fantoni

  2. Centro di Studi Biochimici sul Morbo di Cooley, Via L. Borsari 46, I-44100, Ferrara, Italy

    R. Gambari, G. Raschellà, R. Biagini, M. Tripodi, M. G. Farace, A. Romeo & A. Fantoni

Authors
  1. R. Gambari
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. Raschellà
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. Biagini
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. Tripodi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M. G. Farace
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. A. Romeo
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. A. Fantoni
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

This work was supported by grants from the Italian National Research Council (C.N.R.) G. R. is a recipient of a fellowship from the National Committee for Nuclear Energy, Rome. Address for reprint requests: R. G., Centro di Studi Biochimici, Via L. Borsari 46, I-44100 Ferrara.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gambari, R., Raschellà, G., Biagini, R. et al. Predominant expression of σ and ε globin genes in human leukemia K-562(S6) variant cell line. Experientia 39, 415–416 (1983). https://doi.org/10.1007/BF01963156

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01963156

Keywords

Search

Navigation