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Evaluation of monoaminergic receptors in the genetically epilepsy prone rat

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Summary

The intensity of sound-induced convulsions in the genetically epilepsy-prone rat (GEPR) was reduced in a dose related fashion by intracerebroventricular administration of dobutamine, (β1 agonist), terbutaline (β2 agonist) or phenylephrine (α1 agonist). BHT-920 (α2 agonist) did not cause a dose-related decrease in sound-induced convulsion intensity. Binding studies showed that whole brain α and β receptor densities (Bmax) were normal while the Kd was increased for the β ligand in GEPR brain.

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Authors and Affiliations

  1. Department of Pharmacology and Psychiatry, Louisiana State University Medical Center and Veterans Administration Medical Center, 71130, Shreveport, Louisiana, USA

    K. H. Ko, J. W. Dailey & P. C. Jobe

Authors
  1. K. H. Ko
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  2. J. W. Dailey
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  3. P. C. Jobe
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Additional information

Acknowledgment. We are most grateful to Boehringer Ingelheim for generously supplying BHT 920. We are also indebted to Ciba-Geigy Corporation for the gift of terbutaline hydrochloride and phentolamine hydrochloride. The work was supported in part by NIH grant NS 16829.

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Ko, K.H., Dailey, J.W. & Jobe, P.C. Evaluation of monoaminergic receptors in the genetically epilepsy prone rat. Experientia 40, 70–73 (1984). https://doi.org/10.1007/BF01959107

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