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Ethanol diminishes the toxicity of the mushroomAmanita phalloides

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Summary

Survival of mice after lethal doses of a lyophilizate fromAmanita phalloides (‘death cap’) was markedly increased by single doses of ethanol applied 30 min before or 5 min after the mushroom. Hepatic histopathological damage (confluent necrosis) was largley prevented. Acute, but not chronic, consumption of ethanol may thus influence favorably the outcome of death cap poisoning and should be taken into consideration in the evaluation of therapeutic measures.

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Authors and Affiliations

  1. Department of Surgery and Research, Zentrum für Lehre und Forschung, Kantonsspital, Hebelstrasse 20, CH-4031, Basel, Switzerland

    G. L. Floersheim & L. Bianchi

  2. Department of Pathology, Kantonsspital, CH-4031, Basel, Switzerland

    G. L. Floersheim & L. Bianchi

Authors
  1. G. L. Floersheim
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  2. L. Bianchi
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Floersheim, G.L., Bianchi, L. Ethanol diminishes the toxicity of the mushroomAmanita phalloides. Experientia 40, 1268–1270 (1984). https://doi.org/10.1007/BF01946668

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  • DOI: https://doi.org/10.1007/BF01946668

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