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Low-molecular-weight enzyme inhibitors suppress the development of experimental allergic encephalomyelitis

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Summary

We tested the activity of low-molecular-weight enzyme inhibitors with immunomodifying actions on the suppression of experimental allergic encephalomyelitis (EAE). Of the agents tested the inhibitors of alkaline phosphatase, aminopeptidase B and esterase gave significant protection againts the clinical expression of EAE in guinea pigs.

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References

  1. Umezawa, H., in: Recent Results in Cancer Research, vol. 76, p. 767. Eds S. K. Carter, Y. Sakurai and H. Umezawa. Springer Verlag, Berlin 1981.

    Google Scholar 

  2. Holborow, E. J., and Swannel, A. J., in: Immunology in Medicine, p. 560. Eds E. J. Holborow and W. G. Reeves. Academic Press, London 1977.

    Google Scholar 

  3. Müller, W. E. G., Schuster, D. K., Maidhof, A., Leyhausen, G., Falke, D., and Umezawa, H., Int. J. Immunopharmac.4 (1982) 393.

    Article  Google Scholar 

  4. Aoyagi, T., and Umezawa, H., in: Industrial and Clinical Enzymology, p. 89. Eds Lj. Vitale, and V. Simeon. Pergamon Press, Oxford 1980.

    Google Scholar 

  5. Yasuda, T., Tsumita, T., and Nagai, Y., Jap. J. exp. Med.45 (1975) 415.

    CAS  PubMed  Google Scholar 

  6. Aoyagi, T., Wada, T., Ishikawa, Y., Kojima, F., Nagai, M., Osanai, T., Nagai, Y., and Umezawa, H., J. Pharm. Dyn.6 (1983) 963.

    Article  CAS  Google Scholar 

  7. Aoyagi, T., Yamamoto, T., Kojiri, K., Kojima, F., Hamada, M., Takeuchi, T., and Umezawa, H., J. Antibiot.31 (1978) 244.

    Article  CAS  Google Scholar 

  8. Umezawa, H., Aoyagi, T., Ohuchi, S., Okuyama, A., Suda, H., Takita, T., Hamada, M., and Takeuchi, T., J. Antibiot.36 (1983) 1572.

    Article  CAS  Google Scholar 

  9. Umezawa, H., Aoyagi, T., Hazato, T., Uotani, K., Kojima, F., Hamada, M., and Takeuchi, T., J. Antibiot.31 (1978) 639.

    Article  CAS  Google Scholar 

  10. Aoyagi, T., Tobe, H., Kojima, F., Hamada, M., Takeuchi, T., and Umezawa, H., J. Antibiot.31 (1978) 636.

    Article  CAS  Google Scholar 

  11. Umezawa, H., Aoyagi, T., Uotani, K., Hamada, M., Takeuchi, T., and Takahashi, S., J. Antibiot.33 (1980) 1594.

    Article  CAS  Google Scholar 

  12. Aoyagi, T., Wada, T., Iwabuchi, M., Kojima, F., Nagai, M., and Umezawa, H., Biochem. int.5 (1982) 97.

    CAS  Google Scholar 

  13. Brosnan, C. F., Cammer, W., Norton, W. T., and Bloom, B. R., Nature285 (1980) 235.

    Article  CAS  PubMed  Google Scholar 

  14. Van Belle, H., Biochim. biophys. Acta289 (1972) 158.

    Article  PubMed  Google Scholar 

  15. Oldham, R. K., and Smalley, R. V., J. Biol. Resp. Modif.2 (1983) 1.

    CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Enzymology, Institute of Microbial Chemistry, Shinagawa-ku, 141, Tokyo, Japan

    T. Aoyagi, T. Wada, M. Nagai, H. Sakaguchi, T. Osanai, Y. Nagai & H. Umezawa

  2. Department of Pathology, School of Medicine, Keio University, Shinjuku-ku, 160, Tokyo, Japan

    T. Aoyagi, T. Wada, M. Nagai, H. Sakaguchi, T. Osanai, Y. Nagai & H. Umezawa

  3. Department of Biochemistry, Faculty of Medicine, University of Tokyo, Bunkyo-ku, 113, Tokyo, Japan

    T. Aoyagi, T. Wada, M. Nagai, H. Sakaguchi, T. Osanai, Y. Nagai & H. Umezawa

Authors
  1. T. Aoyagi
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  2. T. Wada
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  3. M. Nagai
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  4. H. Sakaguchi
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  5. T. Osanai
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  6. Y. Nagai
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  7. H. Umezawa
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Additional information

Acknowledgments. This work was partly supported by a grant-in-aid for New Drug Development Research from the Ministry of Health and Welfare, Japan.

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Aoyagi, T., Wada, T., Nagai, M. et al. Low-molecular-weight enzyme inhibitors suppress the development of experimental allergic encephalomyelitis. Experientia 40, 1405–1407 (1984). https://doi.org/10.1007/BF01951914

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  • DOI: https://doi.org/10.1007/BF01951914

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