Summary
The long-term effect of ocular administration of a substance P (SP) antagonist, (D-Pro2, D-Trp7,9)-SP, was studied in the rabbit. After 2–3 months of topical administration of the antagonist twice daily, a mild trauma was applied in the form of infrared irradiation of the iris. The control eye responded with disruption of the blood-aqueous barrier, the eye treated with the antagonist did not. Two days after termination of treatment, the response to ocular injury was still reduced. Another 2 days later, ocular injury evoked a normal response, which shows that the protection was reversible. No adverse reaction to the SP antagonist was noted.
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This paper has been selected as a winner by the Swedish jury of the Chibret International Award. The work was supported by the Swedish MRC (04X-1007), the Medical Faculty of Lund, Ferring Pharmaceutical, Malmö, Sweden, Ferring Arzneimittel, Kiel, FRG and the Robert A. Welch Foundation.
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Bynke, G., Håkanson, R., Hörig, J. et al. Long-term administration of a substance P antagonist, (D-Pro2, D-Trp7,9)-SP, abolishes the response to ocular trauma. Experientia 40, 368–369 (1984). https://doi.org/10.1007/BF01952556
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DOI: https://doi.org/10.1007/BF01952556