Skip to main content
Log in

Binding of centchroman—a nonsteroidal antifertility agent to human plasma proteins

  • Published:
Experientia Aims and scope Submit manuscript

Summary

Centchroman, a non-steroidal antifertility agent showed a low affinity (Kd=13.19×10−6 M) and nonsaturable binding to human plasma. Centchroman did not complete either with sex hormone binding globulin or corticosteroid binding globulin. Polyacrylamide gel electrophoresis and temperature dependent binding characteristics revealed that the protein responsible for centchroman binding to human plasma resembles albumin.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Kamboj, V. P., Kar, A. B., Roy, S., Grover, P. K., and Anand, N., Ind. J. exp. Biol.9 (1971) 103.

    CAS  Google Scholar 

  2. Kamboj, V. P., Singh, M. M., and Kar, A. B., Ind. J. exp. Biol.11 (1973) 479.

    CAS  Google Scholar 

  3. Durani, S., and Anand, N., Int. J. Quant. Chem.20 (1981) 71.

    Article  CAS  Google Scholar 

  4. Westphal, U., Stroupe, S. D., and Cheng, S. L., Ann. N.Y. Acad. Sci.286 (1977) 10.

    Article  CAS  PubMed  Google Scholar 

  5. Jenkins, N., and Fotherby, K., J. Steroid Biochem.13 (1980) 521.

    Article  CAS  PubMed  Google Scholar 

  6. Srivastava, A. K., and Roy, S. K., Experientia39 (1983) 157.

    Article  CAS  PubMed  Google Scholar 

  7. Srivastava, A. K., J. Steroid Biochem.9 (1978) 1241.

    Article  CAS  PubMed  Google Scholar 

  8. Ritzen, E. M., French, F. S., Weddington, S. C., Nayfeh, S. N., and Hansson, V., J. biol. Chem.249 (1974) 6597.

    Article  CAS  PubMed  Google Scholar 

  9. Pearlman, W. H., and Crepy, O., J. biol. Chem.242 (1967) 182.

    Article  CAS  PubMed  Google Scholar 

  10. Nilsson, B., Sodergard, R., Damber, M., and Schoultz, B., Fert. Steril.38 (1982) 48.

    Article  CAS  Google Scholar 

  11. Faye, J. C., Lesserre, B., and Bayard, F., Biochem. biophys. Res. Commun.93 (1980) 1225.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

Acknowledgment. The authors are grateful to Dr. Nitya Nand for his interest in this investigation. CDRI Communication No. 3333.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Srivastava, A.K., Agnihotri, A. & Kamboj, V.P. Binding of centchroman—a nonsteroidal antifertility agent to human plasma proteins. Experientia 40, 465–466 (1984). https://doi.org/10.1007/BF01952388

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01952388

Keywords

Navigation