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Inhibition of brain enolases by acrylamide and its related compounds in vitro, and the structure-activity relationship

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Summary

Acrylamide and its related compounds inhibited brain enolases in vitro independently of their neurotoxicity. The inhibitory potency was a function of the binding constants of the compounds for phenylalanine. The binding constant for tryptophan was higher in neurotoxic compounds than in non-neurotoxic ones.

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Authors and Affiliations

  1. Department of Hygiene, School of Medicine, Kanazawa University, 13-1, Takara-machi, 920, Kanazawa, (Japan)

    H. Tanii & K. Hashimoto

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  1. H. Tanii
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  2. K. Hashimoto
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Tanii, H., Hashimoto, K. Inhibition of brain enolases by acrylamide and its related compounds in vitro, and the structure-activity relationship. Experientia 40, 971–972 (1984). https://doi.org/10.1007/BF01946464

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  • DOI: https://doi.org/10.1007/BF01946464

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