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Selective effects of gonadal steroids on the response of peripheral serotonin receptors

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Summary

The maximal contraction provoked by serotonin (5-HT) in isolated stomach strips of adult rats, a functional index for peripheral 5-HT receptors, was sexually differentiated, androgen-sensitive, and estrogen refractory. This is at variance with the reported sensitivity of central 5-HT receptors to estrogen.

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References

  1. Biegon, A., Reches, A., Snyder, L., and McEwen, B.S., Life Sci.32 (1983) 2015.

    Article  CAS  PubMed  Google Scholar 

  2. McEwen, B.S., Davis, P.G., Parsons, B., and Pfaff, D.W., A. Rev. Neurosci.2 (1979) 65.

    Article  CAS  Google Scholar 

  3. Glennon, R.A., Res. Commun. Psychol. Psychiat. Behav.4 (1979) 333.

    CAS  Google Scholar 

  4. Leysen, J.E., and Tollenaere, J.P., A. Rep. Med. Chem.17 (1982) 1.

    CAS  Google Scholar 

  5. Frankhuijzen, A.L., and Bonta, I.C., Eur. J. Pharmac.26 (1974) 220.

    Article  CAS  Google Scholar 

  6. Heltzel, J.A., and Vogel, W.H., in: CNS receptors — from moleclar pharmacology to behavior, p. 385. Raven Press, New York 1983.

    Google Scholar 

  7. Vaccari, A., Caviglia, A., Sparatore, A., and Biassoni, R., J. Neurochem.37 (1981) 640.

    Article  CAS  PubMed  Google Scholar 

  8. Offermeier, J., in: Serotonin and its derivatives. A study on structure-activity relations, p. 45. Thesis, Thoben Offset, Nijmegen 1965.

    Google Scholar 

  9. Van Rossum, J.M., Archs int. Pharmacodyn. Thér.143 (1963) 299.

    Google Scholar 

  10. Ariëns, E.J., and Van Rossum, J.M., Archs int. Pharmacodyn. Thér.110 (1957) 275.

    Google Scholar 

  11. Vaccari, A., and Cugurra, F., Biochem. Pharmac.17 (1968) 824.

    Article  CAS  Google Scholar 

  12. Döhler, D., and Wuttke, W., Endocrinology97 (1975) 898.

    Article  PubMed  Google Scholar 

  13. Hàva, M., and Helfert, I., Archs int. Pharmacodyn. Thér.166 (1967) 79.

    Google Scholar 

  14. Ishida, Y., Oshima, H., Aibara, S., and Ohmoto, M., Yakugaku Zasshi92 (1972) 1175.

    Article  CAS  PubMed  Google Scholar 

  15. Greenberg, S., Kadowitz, P.J., Schedl, H.P., and Long, J.P., J. Pharmac. exp. Ther.185 (1973) 505.

    CAS  Google Scholar 

  16. Seaman, I., Fontaine, J., Famaey, J.P., and Reuse, J., Archs int. Pharmacodyn. Thér.230 (1977) 340.

    CAS  Google Scholar 

  17. Fontaine, J., Seaman, I., Famaey, J.P., and Reuse, J., J. Pharm. Pharmac.31 (1979) 186.

    Article  CAS  Google Scholar 

  18. Vaccari, A., in: Biogenic amines in development, p. 327. Elsevier/North-Holland Biomed. Press, Amsterdam 1980.

    Google Scholar 

  19. Nelson, D.L., Weck, B., and Taylor, W., in: CNS receptors — from molecular pharmacology to behavior, p. 338. Raven Press, New York 1983.

    Google Scholar 

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Vaccari, A. Selective effects of gonadal steroids on the response of peripheral serotonin receptors. Experientia 41, 407–408 (1985). https://doi.org/10.1007/BF02004531

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