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NADP-isocitric dehydrogenase of gerbil adrenal mitochondria: Support of steroid hydroxylation

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In gerbil adrenal cortex the activity of intramitochondrial NADP-linked isocitric dehydrogenase (IDH) is up to 10-fold greater than the NAD-linked IDH. The NADP-IDH, apparent Km 0.58 mM, Vmax 280 nmoles/min/mg mitochondrial protein, appears to be the major source of reducing equivalents to support adrenal mitochondrial steroid 11B- and 19-hydroxylation in this species.

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Authors and Affiliations

  1. Department of Biology, Southern Methodist University, 75275, Dallas, Texas, USA

    J. L. McCarthy & J. Gauthier

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  1. J. L. McCarthy
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  2. J. Gauthier
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McCarthy, J.L., Gauthier, J. NADP-isocitric dehydrogenase of gerbil adrenal mitochondria: Support of steroid hydroxylation. Experientia 41, 484–485 (1985). https://doi.org/10.1007/BF01966160

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  • DOI: https://doi.org/10.1007/BF01966160

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