Summary
Two sulfur-containing ansamycin antibiotics were isolated from the culture broth ofStreptomyces albolongus C-46366; the major one was identical with awamycin and the minor one was a new ansamycin antibiotic, ansathiazin. Their structures were elucidated from their reactions and spectroscopic analyses. These antibiotics were active against gram-positive bacteria, acid-fast bacteria and a protozoan.
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We thank Dr I. Umezawa for his generous gift of awamycin. We are grateful to Drs K. Morita, Y. Nakao, H. Okazaki and H. Ono for their interest throughout this work. Thanks are also due to Messrs Y. Kono, K. Koyama, H. Fujiuchi and Y. Nakano, and Mrs K. Jinno for their skillful technical assistance.
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Tanida, S., Shinagwa, S., Takizawa, M. et al. Two sulfur-containing ansamycin antibiotics fromStreptomyces albolongus . Experientia 42, 1167–1170 (1986). https://doi.org/10.1007/BF01941296
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DOI: https://doi.org/10.1007/BF01941296