Skip to main content
SpringerLink
Log in

Cellular and secreted tumor plasminogen activator: The effects of NaCl

  • Short Communications
  • Published:
Experientia Aims and scope Submit manuscript

Summary

Plasminogen activator, secreted by metastatic tumor cells, was strongly inhibited in buffer or tissue culture medium containing physiological concentrations of NaCl. Intact cells, however, expressed strong activity under similar conditions. Thus, if plasminogen activator is involved in invasion and metastasis, the cellular activity, acting as an ectoenzyme, may be more important than secreted enzyme under physiological conditions.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Mullins, D.E., and Rohrlich, S.T., Biochim. biophys. Acta695 (1983) 214.

    Google Scholar 

  2. Nicolson, G.L., Biochim. biophys. Acta695 (1982) 113.

    CAS  PubMed  Google Scholar 

  3. Nicolson, G.L., and Poste, G., Int. Rev. exp. Path.25 (1983) 77.

    CAS  PubMed  Google Scholar 

  4. Wang, B.S., McLoughlin, G.A., Richie, J.P., and Mannick, J.A., Cancer Res.40 (1980) 288.

    CAS  PubMed  Google Scholar 

  5. Ng, R., Kellen, J.A., and Wong, A.C.H., Invasion Metastasis3 (1984) 243.

    Google Scholar 

  6. Talmadge, J.E., Starkey, J.R., and Stanford, R., J. supramolec. Struct. cell. Biochem.15 (1981) 139.

    Article  CAS  Google Scholar 

  7. Danø, K., and Reich, E., Biochim. biophys. Acta566, (1979) 138.

    Article  PubMed  Google Scholar 

  8. Aggeler, J., Risch, J., and Werb, Z., Biochim. biophys. Acta675 (1981) 62.

    Article  CAS  PubMed  Google Scholar 

  9. Wijngaards, G., Thromb. Haemost.41 (1979) 590.

    Article  CAS  PubMed  Google Scholar 

  10. Radcliffe, R., and Heinze, T., in: The Regulation of Coagulation, p. 551, Eds K.G. Mann and F.B. Taylor. Elsevier North Holland Inc., Amsterdam 1980.

    Google Scholar 

  11. Lemaire, G., Drapier, J.C., and Petit, J.F., Biochim. biophys. Acta755 (1983) 332.

    Article  CAS  PubMed  Google Scholar 

  12. Stephens, R.W., and Golder, J.P., Eur. J. Biochem.19 (1984) 253.

    Article  Google Scholar 

  13. Carlsen, S.A., Ramshaw, I.A., and Warrington, R.C., Cancer Res.44 (1984) 3012.

    CAS  PubMed  Google Scholar 

  14. Barrett, J.C., Crawford, B.D., and Ts'o, P.O.P., Cancer Res.37 (1977) 1182.

    CAS  PubMed  Google Scholar 

  15. Quigley, J.P., J. Cell Biol.71 (1976). 472.

    Article  CAS  PubMed  Google Scholar 

  16. Quigley, J.P., Goldfarth, R.H., Scheiner, C., O'Donnell-Tormey, J., and Yeo, T.T., in: Tumor Cell Surfaces and Malignancy, p. 773. Eds R.O. Hynes and C.F. Fox. Alan R. Liss Inc., New York 1980.

    Google Scholar 

  17. Chapman, H.A., Vavrin, Z., and Hibbs, J.B., Cell28 (1982) 653.

    Article  CAS  PubMed  Google Scholar 

  18. Badenoch-Jones, P., Ramshaw, I.A., and Grant, A., Aust. J. exp. Biol. med. Sci.63 (1985) 343.

    Article  CAS  PubMed  Google Scholar 

  19. Liu, H.V., Peltz, S.W., and Mangel, W.F., Molec. cell. Biol.2 (1982) 1410.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Experimental Pathology, John Curtin School of Medical Research, P.O. Box 334, 2602, Canberra, ACT, Australia

    P. Badenoch-Jones, I. A. Ramshaw & A. Grant

Authors
  1. P. Badenoch-Jones
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. I. A. Ramshaw
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Grant
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Badenoch-Jones, P., Ramshaw, I.A. & Grant, A. Cellular and secreted tumor plasminogen activator: The effects of NaCl. Experientia 42, 433–435 (1986). https://doi.org/10.1007/BF02118645

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02118645

Key words

Search

Navigation