Skip to main content
SpringerLink
Log in

A new semisynthetic ergot peptide alkaloid: DCN 203-922

  • Short Communications
  • Published:
Experientia Aims and scope Submit manuscript

Summary

We report the synthesis, stereochemistry and preliminary pharmacological evaluation of DCN 203-922, a novel ergot alkaloid of the cyclol type, which contains in its peptide moiety the uncommon amino acid L-allo-isoleucine.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Berde, B., and Schild, H.O., Ergot Alkaloids and Related Compounds. Springer, Berlin 1978.

    Book  Google Scholar 

  2. Stadler, P.A., and Giger, R.K.A., Ergot Alkaloids and Their Derivatives in Medicinal Chemistry and Therapy. Alfred Benzon Symposium 20, pp. 463–85. Munksgaard, Copenhagen 1984.

    Google Scholar 

  3. Maurer, G., Schreier, E., Delaborde, S., Loosli, H.R., Nufer, R., and Shukla, A.P., Eur. J. Drug Metab. Pharmacokin.7 (1982) 281 and Maurer, G., Schreier, E., Delaborde, S., Nufer, R. and Shukla, A.P., Eur. J. Drug. Metab. Pharmacokin.8 (1983) 51.

    Article  CAS  Google Scholar 

  4. Bada, J.L., Zhao, M., Steinberg, S., and Ruth, E., Nature319 (1986) 314–316.

    Article  CAS  Google Scholar 

  5. Halpern, B., and Pollock, G.E., Biochem. Med.4 (1970) 352.

    Article  CAS  PubMed  Google Scholar 

  6. Hofmann, A., Frey, A.J., and Ott, H., Experientia17 (1961) 206.

    Article  CAS  PubMed  Google Scholar 

  7. Giger, R.K.A., Offenlegungsschrift DE 33 03 616 A1 (1983).

  8. Organic Syntheses, Coll. Vol. I 36–38 and III 495–498.

  9. Bartlett, P.A., Tanzella, D.J., and Barstow, J.F., Tetrahedron Lett.23 (1982) 619.

    Article  CAS  Google Scholar 

  10. Oppolzer, W., Pedrosa, R., and Moretti, R., Tetrahedron Lett.27 (1986) 831.

    Article  CAS  Google Scholar 

  11. Lindner, H.J., Tetrahedron30 (1974) 1127.

    Article  CAS  Google Scholar 

  12. Vigouret, J.M., Buerki, H.R., Jaton, A.L., and Loew, D.M., Pharmacology16 (1978) 156.

    Article  CAS  PubMed  Google Scholar 

  13. Shelesnyak, M.C., Proc. 1st int. Congr. Endocr., p. 677. Copenhagen 1960.

  14. Siegl, H., unpublished results.

  15. Giger, R.K.A., and Vigouret, J.M. International Congress of Gerontology, New York, July 1984.

Download references

Author information

Authors and Affiliations

  1. Preclinical Research, Sandoz Ltd., CH-4002, Basel, Switzerland

    R. K. A. Giger, H. R. Loosli, M. D. Walkinshaw, B. J. Clark & J. M. Vigouret

Authors
  1. R. K. A. Giger
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. R. Loosli
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. D. Walkinshaw
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. B. J. Clark
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. J. M. Vigouret
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Part of this paper was reported by this author at the Herbstversammlung der Schweizerischen Chemischen Gesellschaft, Bern, in October 1986.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Giger, R.K.A., Loosli, H.R., Walkinshaw, M.D. et al. A new semisynthetic ergot peptide alkaloid: DCN 203-922. Experientia 43, 1125–1130 (1987). https://doi.org/10.1007/BF01956061

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01956061

Key words

Search

Navigation