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Choline accumulation in isolated rat hepatocytes

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Summary

The accumulation of non-metabolized choline in isolated rat hepatocytes is concentrative in Na+ medium, whereas the accumulation does not exceed unity in a Li+ medium. Ouabain and 2,4-dinitrophenol inhibited the choline uptake. These results indicate that choline is taken up by rat hepatocytes via a Na+-and energy-dependent process, and choline oxidase is not directly connected with the choline transport system.

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Authors and Affiliations

  1. Department of Medical Biochemistry, Shiga University of Medical Science, Seta, 520-21, Ohtsu, Japan

    K. Yoshioka

  2. Department of Biochemistry, Kyoto Prefectural University of Medicine, 602, Kamikyo-ku, Kyoto, Japan

    H. Nishimura

Authors
  1. K. Yoshioka
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  2. H. Nishimura
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Yoshioka, K., Nishimura, H. Choline accumulation in isolated rat hepatocytes. Experientia 44, 889–892 (1988). https://doi.org/10.1007/BF01941191

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  • DOI: https://doi.org/10.1007/BF01941191

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