Summary
We have cloned part of theETS 1 proto-oncogene and demonstrated the presence of two polymorphic Sst I restriction sites. A probe derived from one of our clones revealed the presence of 8.3 kb, 9.5 kb and/or 11.5 kb fragments on Southern blots of human DNA samples. The relative frequencies of these alleles appear to be significantly different between Saudi and Western populations, but there are no apparent differences in these frequencies between Saudi non-leukemic and leukemic individuals.
References
Goyns, M. H., Cancer J.1 (1986) 183.
Chen, J. H., Molec. cell. Biol.5 (1985) 2993.
DeTaisne, C., Gegonne, A., Stehelin, D., Bernheim, A., and Berger, R., Nature310 (1984) 581.
Arthur, D. C., Bloomfield, C. D., Lindquist, L. L., and Nesbit, M. E., Blood59 (1982) 96.
Goyns, M. H., Hann, I. M., Stewart, J., Gegonne, A., and Birnie, G. D., Br. J. Cancer56 (1987) 611.
Benton, W. D., and Davis, R. W., Science196 (1972) 180.
Maniatis, T., Fritsch, E. F., and Sambrook, J., in: Molecular Cloning, a Laboratory Manual, Cold Spring Harbor Laboratory, New York 1982.
Gros-Bellard, M., Oudet, P., and Chambon, P., Eur. J. Biochem.36 (1973) 32.
Thein, S. L., Oscier, D. G., Flint, J., and Wainscoat, J. S., Nature321, (1986) 84.
Wiggs, J., Nordenskjold, M., Yandell, D., Rapaport, J. and Grodin, V., New Engl. J. Med.318 (1988) 151.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Parkar, M.H., Seid, J.M., Rowson, J.M. et al. Restriction fragment length polymorphisms in theETS-1 proto-oncogene Comparison of Saudi and Western populations. Experientia 44, 1019–1020 (1988). https://doi.org/10.1007/BF01939909
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01939909