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Feeding induced by blockade of histamine H1-receptor in rat brain

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Histamine antagonists were infused into the third ventricle of the cerebrum in rats. All the H1-, but none of the H2-antagonists tested, induced initial feeding during the early portion of the light phase when histamine level was highest. No periprandial drinking was observed. Ambulation increased during feeding. The effect on feeding was attenuated when brain histamine was normally low during the early portion of the dark phase, or was decreased by α-fluoromethylhistidine. Hypothalamic neuronal histamine may suppress food intake through H1-receptors, and diurnal fluctuations of food intake may mirror neuronal histamine levels.

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Authors and Affiliations

  1. Department of Internal Medicine I, Faculty of Medicine Kyushu University 71, 812, Fukuoka, Japan

    T. Sakata, K. Fukagawa, K. Fujimoto & H. Yoshimatsu

  2. Department of Physiology, School of Medicine, Tokai University, Isehara, 259-11, Kanagawa, Japan

    T. Shiraishi

  3. Department of Pharmacology II, Osaka University Medical School, 530, Osaka, Japan

    H. Wada

Authors
  1. T. Sakata
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  2. K. Fukagawa
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  3. K. Fujimoto
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  4. H. Yoshimatsu
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  5. T. Shiraishi
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  6. H. Wada
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Sakata, T., Fukagawa, K., Fujimoto, K. et al. Feeding induced by blockade of histamine H1-receptor in rat brain. Experientia 44, 216–218 (1988). https://doi.org/10.1007/BF01941710

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  • DOI: https://doi.org/10.1007/BF01941710

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