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Hepatic phosphatidylcholine synthesis in deficiency of lysine and threonine: effect of malathion

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Summary

Rats fed on a rice diet deficient in lysine and threonine showed increased activities of CDP-Choline pathway enzymes and incorporation of (methyl-3H)-choline into hepatic microsomal phosphatidylcholine, compared to rats fed on the same diet supplemented with lysine and threonine. However, the amount of microsomal phosphatidylcholine was significantly decreased in rats fed a deficient rice diet. These results suggest an enhanced phosphatidylcholine catabolism in rats fed on a rice diet deficient in lysine and threonine. Malathion administration reduced the amount of phosphatidylcholine in all the groups.

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Author notes

  1. Y. Singh

    Present address: Division of Bacteriology, USAMRIID, Fort Detrick, 21701, Frederick, MD, USA

Authors and Affiliations

  1. Department of Biochemistry, V.P. Chest Institute, University of Delhi, 110 007, Delhi, India

    Y. Singh, V. K. Chaudhary, R. Bhatnagar & U. K. Misra

  2. Division of Bacteriology, USAMRIID, Fort Detrick, 21701, Frederick, MD, USA

    S. R. Tyagi

Authors
  1. Y. Singh
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  2. V. K. Chaudhary
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  3. S. R. Tyagi
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  4. R. Bhatnagar
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  5. U. K. Misra
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Singh, Y., Chaudhary, V.K., Tyagi, S.R. et al. Hepatic phosphatidylcholine synthesis in deficiency of lysine and threonine: effect of malathion. Experientia 44, 758–759 (1988). https://doi.org/10.1007/BF01959153

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  • DOI: https://doi.org/10.1007/BF01959153

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