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Comparative platelet anti-aggregant activity of D-cysteinolic acid analogues

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Summary

D-Cysteinolic acid (1) analogues with an S-C-C-N skeleton showed increased platelet anti-aggregant activity in the following order: 2-aminoethanesulfonic acids, thiazolidines, 2-aminoethanethiols and 2-aminoethyl disulfides. Methyl substitutions at the 2-position potentiated the activity. Of these analogues, bis [(R)-2-aminopropyl] disulfide was the most potent inhibitor of platelet aggregation, with about 600-fold the activity of (1).

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Authors and Affiliations

  1. Central Research Laboratory, Nippon Suisan Co. Ltd., Kitanocho 559-6, 192, Hachiohji, Tokyo, Japan

    M. Satake & Y. Chiba

  2. Faculty of Pharmaceutical Sciences, Osaka University, Yamadaoka 1-6, 565, Suita, Osaka, Japan

    Y. Kohama, K. Yamamoto, M. Okabe, T. Mimura, T. Imanishi & C. Iwata

Authors
  1. M. Satake
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  2. Y. Chiba
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  3. Y. Kohama
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  4. K. Yamamoto
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  5. M. Okabe
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  6. T. Mimura
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  7. T. Imanishi
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  8. C. Iwata
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Satake, M., Chiba, Y., Kohama, Y. et al. Comparative platelet anti-aggregant activity of D-cysteinolic acid analogues. Experientia 45, 1110–1112 (1989). https://doi.org/10.1007/BF01950172

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  • DOI: https://doi.org/10.1007/BF01950172

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