Summary
Dose-dependent relaxations were induced by dopamine in human pulmonary arteries that had been contracted with prostaglandin F2α without α-adrenergic blocking agents. The dopamine-induced relaxation was inhibited by haloperidol and fluphenazine, but not by domperidone, suggesting that this relaxation was mediated via DA1 receptors.
References
Goldberg, L. I., and Toda, N., Circ. Res.36 and37, suppl. I (1975) 197.
Goldberg, L. I., Glock, D., Kohli, J. D., and Barnett, A., Hypertension6, suppl. I (1984) 125.
Brodde, O.-E., Freistühler, J., and Meyer, F.-J., J. cardiovasc. Pharmac.3 (1981) 828.
Ohlstein, E. H., Zabko-Potapovich, B., and Berkowitz, B. A., J. Pharmac. exp. Ther.229 (1984) 433.
Ueda, S., Yano, S., and Sakanashi, M., J. cardiovasc. Pharmac.4 (1982) 76.
Toda, N., Experientia39 (1983) 1131.
Forester, C., Drew, G. M., Hilditch, A., and Whalley, E. T., Eur. J. Pharmac.87 (1983) 227.
Hoshino, Y., Obara, H., and Iwai, S., Life Sci.39 (1986) 2525.
Holloway, E. L., Polumbo, R. A., and Harrison, D., Br. Heart J.37 (1975) 482.
Goldberg, L. I., and Rajfer, S., Circulation72 (1985) 245.
Young, J. B., Leon, C. A., Pratt, C. M., Suarez, J. M., Aronoff, R. D., and Roberts, R., J. Am. Coll. Cardiol.6 (1985) 792.
Muramatsu, I., Oshita, M., and Yamanaka, K., J. Pharmac. exp. Ther.227 (1983) 194.
Toda, N., and Goldberg, L. I., Cardiovasc. Res.9 (1975) 384.
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Yamauchi, M., Kobayashi, Y., Hattori, K. et al. Dopamine-induced relaxation in human pulmonary arteries. Experientia 45, 150–152 (1989). https://doi.org/10.1007/BF01954854
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DOI: https://doi.org/10.1007/BF01954854