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Cerebrovascular autoregulation is resistant to calcium channel blockade with nimodipine

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Summary

In normal baboons cerebrovascular resistance changed along with blood pressure to maintain blood flow constant. This ‘autoregulation’ was not significantly altered in animals treated with a dose of the calcium channel blocker nimodipine causing selective cerebral vasodilation.

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Authors and Affiliations

  1. Cerebrovascular Research Laboratory, VA Medical Center, 77004, Houston, Texas, USA

    T. A. McCalden & R. G. Nath

  2. Department of Pharmacology, University of Houston, 77004, Houston, Texas, USA

    T. A. McCalden & R. G. Nath

  3. Pharmacology Department, Liposome Technology Inc., 1050 Hamilton Court, 94025, Menlo Park, CA, USA

    T. A. McCalden

Authors
  1. T. A. McCalden
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  2. R. G. Nath
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McCalden, T.A., Nath, R.G. Cerebrovascular autoregulation is resistant to calcium channel blockade with nimodipine. Experientia 45, 305–306 (1989). https://doi.org/10.1007/BF01951818

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  • DOI: https://doi.org/10.1007/BF01951818

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