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Depletion of hypothalamic norepinephrine reduces the fever induced by polyriboinosinic acid: polyribocytidylic acid (Poly I:Poly C) in rats

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Summary

Administration of either Poly I:Poly C (0.05–0.50 μg) or norepinephrine (2–8 μg) into the anterior hypothalamic area produced a dose-related fever in rats. The fever induced by Poly I:Poly C was attenuated after selective depletion of norepinephrine in the hypothalamus. However, selective depletion of hypothalamic norepinephrine did not affect the fever induced by intrahypothalamic norepinephrine. The data indicate that Poly I:Poly C may act to induce fever through the endogenous release of norepinephrine from the rat's hypothalamus.

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References

  1. Bocci, V., Biomedicine (Paris).32 (1980) 159.

    Google Scholar 

  2. Dinarello, C. A., Bernheim, H. A., Duff, G. W., Le, H. V., Nagabhushan, T. L., Hamilton, N. C., and Coceani, F., J. clin. Invest.74 (1984) 906.

    PubMed  Google Scholar 

  3. Ackerman, S. K., Hochstein, H. D., Zoon, K., Browne, W., Rivera, E., and Elisberg, B., J. Leukocyte Biol.36 (1984) 17.

    PubMed  Google Scholar 

  4. Lindsay, H. L., Trown, P. W., Brandt, J., and Forbes, M., Nature223 (1969) 717.

    PubMed  Google Scholar 

  5. Won, S. J., and Lin, M. T., Am. J. Physiol.254 (1988) R499.

    PubMed  Google Scholar 

  6. Won, S. J., Lin, M. T., Chuang, J., and Huang, K. Y., Chin. J. Physiol.30 (1987) 49.

    PubMed  Google Scholar 

  7. Lin M. T., Chern, Y. F., and Chen, S. Y., Neuropharmacology24 (1985) 1039.

    Article  PubMed  Google Scholar 

  8. Paxinos, G., and Watson, C., The rat brain, in: Stereotaxic Coordinates. Academic Press, Sydney 1982.

    Google Scholar 

  9. Lin, M. T., J. gen. Pharmac.10 (1979) 417.

    Google Scholar 

  10. Lin, M. T., Am. J. Physiol.238 (1980) R364.

    PubMed  Google Scholar 

  11. Lin, M. T., Wu, J. J., Chandra, A., and Tsay, B. L., J. Pharmac. exp. Ther.222 (1982) 251.

    Google Scholar 

  12. Kubiskowski, R., and Rewerski, W., Diss. Pharmac.21 (1969) 207.

    Google Scholar 

  13. Murakami, N. Jpn. J. Physiol.23 (1973) 435.

    PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Physiology, Taipei Medical College, Taipei, (Taiwan, ROC)

    H. J. Liu

  2. Department of Physiology, National Cheng Kung University Medical College, Tainan, (Taiwan, ROC)

    C. M. Young & M. T. Lin

Authors
  1. H. J. Liu
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  2. C. M. Young
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  3. M. T. Lin
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Additional information

This work was supported by grants from the National Science Council (Taipei, Republic of China).

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Liu, H.J., Young, C.M. & Lin, M.T. Depletion of hypothalamic norepinephrine reduces the fever induced by polyriboinosinic acid: polyribocytidylic acid (Poly I:Poly C) in rats. Experientia 45, 720–722 (1989). https://doi.org/10.1007/BF01974567

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  • DOI: https://doi.org/10.1007/BF01974567

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