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9-Methyl-7-bromoeudistomin D, a potent inducer of calcium release from sarcoplasmic reticulum of skeletal muscle

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Summary

The Ca2+-releasing action of several derivatives of eudistomin D isolated from a marine tunicate was compared with that of caffeine. It was found that 9-methyl-7-bromoeudistomin D was approximately 1000 times more potent than caffeine in causing Ca2+ release from the sarcoplasmic reticulum.

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The authors thank Ms A. Muroyama of this institute for her technical assistance and Prof. K. L. Rinehart of University of Illinois for his encouragement.

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Kobayashi, J., Ishibashi, M., Nagai, U. et al. 9-Methyl-7-bromoeudistomin D, a potent inducer of calcium release from sarcoplasmic reticulum of skeletal muscle. Experientia 45, 782–783 (1989). https://doi.org/10.1007/BF01974589

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  • DOI: https://doi.org/10.1007/BF01974589

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