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Metabolism of 3β-hydroxycholest-5-en-26-oic acid in hamsters

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Summary

Metabolism of 26-hydroxycholesterol to 3β-hydroxychol-5-en-24-oic acid and other C24-bile acids has been expected to occur by way of 3β-hydroxycholest-5-en-26-oic acid in studies in vitro. 3β-Hydroxycholest-5-en-26-oic acid was infused intravenously into bile fistula hamsters and the following C24-bile acids were identified: 3β-hydroxychol-5-en-24-oic acid, lithocholic acid, chenodeoxycholic acid, and a small amount of cholic acid.

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References

  1. Wachtel, N., Emerman, S., and Javitt, N. B., J. biol. Chem.243 (1968) 5207.

    Article  CAS  PubMed  Google Scholar 

  2. Kok, E., Burstein, S., Javitt, N. B., Gut, M., and Byon, C. Y., J. biol. Chem.256 (1981) 6155.

    Article  CAS  PubMed  Google Scholar 

  3. Javitt, N. B., Kok, E., Carbhi, F., Blizzard, T., Gut, M., and Byon, C. Y., J. biol. Chem.261 (1986) 12486.

    Article  CAS  PubMed  Google Scholar 

  4. Mitropoulos, K. A., and Myant, N. B., Biochem. J.103, (1967) 472.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Ayaki, Y., Kok, E., and Javitt, N. B., J. biol. Chem.264 (1989) 3818.

    Article  CAS  PubMed  Google Scholar 

  6. Emerman, S., and Javitt, N. B., J. biol. Chem.242 (1967) 661.

    Article  CAS  PubMed  Google Scholar 

  7. Fredrickson, D. S., and Ono, K., Biochim. biophys. Acta22 (1956) 183.

    Article  CAS  PubMed  Google Scholar 

  8. Danielsson, H., Arkiv. Kem.17 (1961) 373.

    CAS  Google Scholar 

  9. Javitt, N. B., Kok, E., Burstein, S., Cohen, B., and Kutschner, J., J. biol. Chem.256 (1981) 12644.

    Article  CAS  PubMed  Google Scholar 

  10. Mitropoulos, K. A., and Myant, N. B., Biochim. biophys. Acta144 (1967) 430.

    Article  CAS  PubMed  Google Scholar 

  11. Usui, T., and Yamasaki, K., Steroids3 (1964) 147.

    Article  CAS  Google Scholar 

  12. Kurkarni, B., and Javitt, N. B., Steroids40 (1982) 581.

    Article  Google Scholar 

  13. Javitt, N. B., and Emerman, S., Mt. Sinai J. Med.37 (1970) 477.

    CAS  PubMed  Google Scholar 

  14. Anderson, K. E., Kok, E., and Javitt, N. B., J. clin. Invest.51 (1972) 112.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department of Biochemistry, Medical School of Tottori University, 683, Yonago, Tottori, Japan

    Y. Ayaki

  2. Division of Hepatic Diseases, New York University Medical Center, 10016, New York, New York, USA

    E. Kok & N. B. Javitt

Authors
  1. Y. Ayaki
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  2. E. Kok
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  3. N. B. Javitt
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Ayaki, Y., Kok, E. & Javitt, N.B. Metabolism of 3β-hydroxycholest-5-en-26-oic acid in hamsters. Experientia 46, 267–269 (1990). https://doi.org/10.1007/BF01951761

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  • DOI: https://doi.org/10.1007/BF01951761

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