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Increased angiogenesis in diabetes

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Summary

Rats with streptozotocin-induced diabetes mellitus showed a 3.4–4.5 times increased angiogenic response following mast-cell activation in situ as compared with age-matched normal controls. The test tissue used was the mesenteric window, which we have previously exploited as a quantitative angiogenesis assay. In the present study two idependent techniques for quantifying the angiogenic response showed essentially the same result. The finding of a pathologically increased angiogenic reaction in the diabetic animals is noteworthy since some of the most harmful complications of diabetes in man relate to proliferative vascular lesions.

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Authors and Affiliations

  1. Department of Pathology, Gothenburg University, Sahlgren's Hospital, S-413 45, Gothenburg, Sweden

    K. Norrby, A. Jakobsson, M. Simonsen & J. Sörbo

Authors
  1. K. Norrby
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  2. A. Jakobsson
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  3. M. Simonsen
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  4. J. Sörbo
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Norrby, K., Jakobsson, A., Simonsen, M. et al. Increased angiogenesis in diabetes. Experientia 46, 856–860 (1990). https://doi.org/10.1007/BF01935538

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