Abstract
In a rat model of hemorrhagic shock which caused the death of all control rats within 30 min, i.v. injection of the ganglion-stimulating drug dimethylphenylpiperazinium (DMPP) caused a dose-dependent reversal of the shock condition-without the need for reinfusion of the shed blood-starting from the dose of 4 ng/kg i.v. Shock reversal was associated with the mobilization of residual blood and improvement in blood flow, particularly at the carotid level. These results could influence our thinking on pathophysiology and first-aid management of shock.
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Literatur
Trunkey, D. D., Sci. Am.249 (1983) 28.
Bellamy, R. F., Milit. Med.149 (1984) 55.
Bellamy, R. F., Maningas, P. A., and Vayer, J. S., Ann. Emerg. Med.15 (1986) 1384.
Baker, C. C., Ann. Emerg. Med.15 (1986) 1389.
Bertolini, A., Guarini, S., and Ferrari, W., Eur. J. Pharmac.122 (1986) 387.
Bertolini, A., Guarini, S., Rompianesi, E., and Ferrari, W., Eur. J. Pharmac.130 (1986) 19.
Bertolini, A., Guarini, S., Ferrari, W., and Rompianesi, E., Life Sci.39 (1986) 1271.
Bertolini, A., Guarini, S., Ferrari, W., Noera, G., Massini, C., and Di Tizio, S., Eur. J. clin. Pharmac.32 (1987) 537.
Pinelli, G., Chesi, G., Di Donato, C., Reverzani, A., and Marani, L., Resuscitation18 (1989) 149.
Noera, G., Pensa, P., Guelfi, P., Biagi, B., Curcio, C., and Bentini, C., Resuscitation18 (1989) 145.
Guarini, S., Tagliavini, S., Bazzani, C., Ferrari, W., and Bertolini, A., Crit. Care Med.18 (1990) 862.
Guarini, S., Ferrari, W., Mottillo, G., and Bertolini, A., Archs int. Pharmacodyn.289 (1987) 311.
Guarini, S., Ferrari, W., and Bertolini, A., Pharmac. Res. Commun.20 (1988) 395.
Guarini, S., Tagliavini, S., Bazzani, C., Benelli, A., Bertolini, A., and Ferrari, W., Resuscitation18 (1989) 133.
Bertolini, A., Ferrari, W., and Guarini, S., Resuscitation18 (1989) 253.
Guarini, S., Rompianesi, E., Ferrari, W., and Bertolini, A., Neuropeptides8 (1986) 19.
Guarini, S., Tagliavini, S., Bazzani, C. Pasini, M., and Bertolini, A., Naunyn-Schmiedeberg's Arch. Pharmac.342 (1990) 36.
Guarini, S., Tagliavini, S., Bazzani, C., Ferrari, W., and Bertolini, A., Pharmac. Res.22 Suppl. 2 (1990) 243.
Guarini, S., Tagliavini, S., Bazzani, C., Ferrante, F., and Bertolini, A., Pharmacology40 (1990) 85.
Guarini, S., Ferrari, W., and Bertolini, A., Naunyn-Schmiedeberg's Arch. Pharmac.337 (1988) 556.
Wang, L., Am. J. Physiol.196 (1959) 188.
Hartley, C. J., and Cole, J. S., J. appl. Physiol.37 (1974) 626.
Wiggers, H. C., Inhraham, R. C., and Dille, J., Am. J. Physiol.143 (1945) 126.
Downie, H. G., and Stevenson, J. A., Can. J. Biochem. Physiol.33 (1955) 436.
Steinam, R. M., and Deustedt, O. F., Can. J. Physiol. Pharmac.47 (1969) 305.
Badanne, m., De Girolami, U., Joris, I., and Majno, G., J. Neuropath. exp. Neurol.42 (1983) 561.
Blahitka, J., and Rakusan, K., Circ. Shock4 (1977) 79.
Ukikusa, M., Kamiyama, Y., and Sato, T., Circ. Shock8 (1981) 483.
Guarini, S., Tagliavini, S., Bazzani, C., Bertolini, A., and Ferrari, W., Naunyn-Schmiedeberg's Arch. Pharmac.343 (1991) 427.
Bertolini, A., Ferrari, W., Guarini, S., and Tagliavini, S., Experientia46 (1990) 704.
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Guarini, S., Bazzani, C., Tagliavini, S. et al. Reversal of experimental hemorrhagic shock by dimethylphenylpiperazinium (DMPP). Experientia 48, 663–667 (1992). https://doi.org/10.1007/BF02118314
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DOI: https://doi.org/10.1007/BF02118314