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Endogenous pyrogen formation by human blood monocytes stimulated by polyriboinosinic acid:Polyribocytidylic acid

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Abstract

The pyrogenic response to supernatants from human blood monocytes stimulated with polyriboinosinic acid:polyribocytidylic acid (poly I:C) was characteristic of a response to endogenous pyrogen in that it was brief and monophasic, and was destroyed by heating the supernatants at 70°C for 30 min. Pyrogen production was unimpaired when the incubations were carried out in the presence of cycloheximide (50 μg/ml; an inhibitor of protein synthesis) or indomethacin (50 μg/ml; an inhibitor of prostaglandin synthesis). Also, neither interferon, interleukins, tumor necrosis factor nor prostaglandin E2 were detectable in the supernatants from the poly I:C-stimulated human monocytes.

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Authors and Affiliations

  1. Department of Microbiology, National Cheng Kung University Medical College, Tainan City, Taiwan (Republic of China)

    S. J. Won

  2. Department of Physiology, National Cheng Kung University Medical College, Tainan City, Taiwan (Republic of China)

    M. T. Lin

Authors
  1. S. J. Won
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  2. M. T. Lin
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Won, S.J., Lin, M.T. Endogenous pyrogen formation by human blood monocytes stimulated by polyriboinosinic acid:Polyribocytidylic acid. Experientia 49, 157–159 (1993). https://doi.org/10.1007/BF01989421

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  • DOI: https://doi.org/10.1007/BF01989421

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