Abstract
We measured plasma levels of adenosine in Dahl salt-sensitive rats (DS) and Dahl salt-resistant rats (DR) to examine the potential role of adenosine in cardiovascular regulation in this type of hypertension. Plasma adenosine concentrations were significantly higher in DS than in DR. The NaCl content in the diet did not affect plasma adenosine concentration in either DS or DR. Significant positive correlation was found between adenosine concentrations and systolic blood pressure when the data for DS and DR were analyzed together. These results suggest that adenosine may play an important role in the pathophysiology of hypertension in DS.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Dunwiddie, T.V., Intl Rev. Neurobiol.27 (1985) 63.
White, T. D., Pharmac. Ther.38 (1988) 129.
Spielman, W. S., and Thompson, C. I., Am. J. Physiol.242 (1982) F423.
Burnstock, G., and Kennedy, C., Circulation Res.58 (1985) 319.
Yamada, K., Goto, A., Yoshioka, M., Matsuoka, H., and Sugimoto, Y., Clin. exp. Pharmac. Physiol.19 (1992) 563.
Biaggioni, I., Hypertension20 (1992) 457.
Londos, C., Copper, D. M. F., and Wolff, J., Proc. natl Acad. Sci. USA77 (1980) 2551.
Edlund, A., Sollevi, A., and Linde, B., Clin. Sci.79 (1990) 131.
Hall, J. E., Granger, J. P., and Hester, R. L., Am. J. Physiol.250 (1986) F917.
Murray, R. D., and Churchill, P. C., Am. J. Physiol.247 (1984) H343.
Sedda, K. O., Bjur, R. A., Shinozuka, K., and Westfall, D. P., J. Pharmac. exp. Ther.252 (1991) 1060.
Katholi, R. E., Hageman, G. R., Whitlow, P. L., and Woods, W. T., Hypertension5 (1983) I–149.
McQuen, D. S., and Ribeiro, J. A., Br. J. Pharmac.88 (1986) 615.
Biaggioni, I., Killian, T. J., Mosqueda-Garcia, R., Robertson, R. M., and Robertson, D., Circulation83 (1991) 1668.
Cox, D. A., Vita, J. A., Treasure, C. B., Fish, R. D., Selwyn, A. P., and Ganz, P., J. clin. Invest.84 (1989) 592.
Katholi, R. E., and Woods, W. T., Clin. exp. Hypertens.9 (1987) 211.
van Buren, M., Bijlsma, J. A., Boer, P., van Rijn, H. J. M., and Koomans, H. A., Hypertension22 (1993) 728.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Yamada, K., Goto, A., Ishii, M. et al. Plasma adenosine concentrations are elevated in Dahl salt-sensitive rats. Experientia 51, 227–229 (1995). https://doi.org/10.1007/BF01931102
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01931102