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Influence of repeated prazosin administration on cardiovascular responses in rats and rabbits

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Abstract

Prazosin was injected i.v. at a dose of 50 μg/kg every 2 h for 8 h in conscious rats. Its hypotensive action significantly declined. A similar effect was also observed in rabbits pretreated with prazosin (40 μg/kg, i.v.) every 1 h for 4 h. In prazosin-treated rabbits, the total peripheral resistance became less responsive to phentolamine stimulation. Repeated prazosin administration abolished its ability to block receptors in a model of anococcygue muscle contraction after noradrenaline (NA) stimulation. The α-adrenoceptors in anococcygue muscle exhibited lower pD2 to NA and lower pA2 to prazosin in prazosin-treated rats. The results demonstrate that repeated prazosin administration reduces the effectiveness of α-adrenoceptors blockers.

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Authors and Affiliations

  1. Studies in Biomedical and Health Science, School of Professional, and Continuing Education, Knowles Building, The University of Hong Kong, Pokfulam Road, Hong Kong

    S. -C. G. Hui

  2. Shantou University Medical College, China

    B. S. Qiu

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  1. S. -C. G. Hui
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  2. B. S. Qiu
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Hui, S.C.G., Qiu, B.S. Influence of repeated prazosin administration on cardiovascular responses in rats and rabbits. Experientia 52, 66–69 (1996). https://doi.org/10.1007/BF01922418

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  • DOI: https://doi.org/10.1007/BF01922418

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