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Lysosomal membrane stabilization by α-tocopherol against the damaging action of Vipera russelli venom phospholipase A2

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Abstract.

This investigation shows the membrane stabilizing effect of α-tocopherol against the damaging action of viper venom phospholipase A2 (PLA2). Liver lysosomal membranes from rats fed 100 mg and 200 mg α-tocopherol acetate per kilogram of diet were more resistant to damage by viper venom PLA2 compared with vitamin E-deficient rats. The membrane stabilizing effect of vitamin E is proposed to be due to the formation of a complex with the phospholipid hydrolysis products of the membrane.

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Received 28 June 1996; accepted 17 July 1996

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Mukherjee, A., Ghosal, S. & Maity, C. Lysosomal membrane stabilization by α-tocopherol against the damaging action of Vipera russelli venom phospholipase A2. CMLS, Cell. mol. life. sci. 53, 152–155 (1997). https://doi.org/10.1007/PL00000586

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  • DOI: https://doi.org/10.1007/PL00000586

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