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Structural view of cadherin-mediated cell-cell adhesion

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Abstract.

Following the multiplication of biochemical, biophysical and structural studies describing cadherin molecules and their interactions, several ideas have emerged to explain the mechanisms of cadherin-mediated cell adhesion. Although different models were proposed for cadherin interactions, a consensus has come forth considering lateral dimerization of cadherins as being a central component of the cell-cell adhesion process. This review summarizes the recent development in structural studies of cadherins.

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Received 14 September 1998; received after revision 14 November 1998; accepted 16 November 1998

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Alattia, J., Kurokawa, H. & Ikura, M. Structural view of cadherin-mediated cell-cell adhesion. CMLS, Cell. Mol. Life Sci. 55, 359–367 (1999). https://doi.org/10.1007/s000180050297

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  • DOI: https://doi.org/10.1007/s000180050297

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