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Analysis and characterization of resorbable dl-lactide-trimethylene carbonate copolyesters

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Randomized copolyesters of dl-lactide (DLLA) and trimethylene carbonate (TMC) in a wide range of composition were synthesized, analysed and characterized with the aim of assessing their potential benefit in biomedical applications. The chemical composition was analysed using 1H-nuclear magnetic resonance (NMR) spectroscopy. Sequence information was obtained by means of 13C-NMR spectroscopy. From the occurrence of TMC-lactate-TMC triads it is concluded that synthesis by melt copolymerization at 190°C is accompanied by transesterification. The copolymers were characterized by means of differential scanning calorimetry (DSC), tensile testing and accelerated hydrolysis tests at 80°C. Their properties were compared with those of the parent polymers. It was found that all properties under investigation are strongly affected by the molar composition: with increasing TMC moieties the glass transition temperature (T g) is depressed, the tensile strength reduced, the elasticity increased and the in vitro hydrolysis rate decelerated.

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  1. Abteilung Entwicklung Chemikalien, Boehringer Ingelheim KG, D-6507, Ingelheim, Germany

    B. Buchholz

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  1. B. Buchholz
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Buchholz, B. Analysis and characterization of resorbable dl-lactide-trimethylene carbonate copolyesters. J Mater Sci: Mater Med 4, 381–388 (1993). https://doi.org/10.1007/BF00122196

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