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Morpholine derivatives

IV. Reaction of methyl iodide and hydrohalic acids with oxacyclobutane derivatives containing morpholinomethyl substituents

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The β-oxide ring of 3-alkyl-3-(N-morpholinomethyl)oxacyclobutanes is opened to give methiodides or hydrohalide salts, respectively, of 2-alkyl-2-(N-morpholinomethyl)-3-halopropanol when they are heated with methyl iodide in methanol under pressure or heated with hydrohalic acids. When two morpholinomethyl groups are present in the 3 position of the oxacyclobutane ring, it is not opened.

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Authors and Affiliations

  1. V. I. Lenin Leningrad Higher Naval-Engineering School. Institute of Experimental Medicine, Academy of Medical Sciences of the USSR, Leningrad

    S. Z. Kaplan, N. A. Zakharova, A. S. Zvontsova, N. V. Khromov-Borisov, S. P. Kozhevnikov & L. V. Pavlyuchenkova

Authors
  1. S. Z. Kaplan
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  2. N. A. Zakharova
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  3. A. S. Zvontsova
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  4. N. V. Khromov-Borisov
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  5. S. P. Kozhevnikov
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  6. L. V. Pavlyuchenkova
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Additional information

See [1] for Communication III.

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1320–1324, October, 1974.

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Kaplan, S.Z., Zakharova, N.A., Zvontsova, A.S. et al. Morpholine derivatives. Chem Heterocycl Compd 10, 1146–1150 (1974). https://doi.org/10.1007/BF00470150

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  • DOI: https://doi.org/10.1007/BF00470150

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