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4-Hydroxy-2-quinolones. 35. Synthesis and study of antithyroid properties of 1H-2-oxo-3-(coumarin-3-yl)-4-hydroxyquinolines

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The methyl ester of 1H-2-oxo-4-hydroxyquinoline-3-acetic acid is condensed in pyridine with salicylaldehydes to 1H-2-oxo-3-(coumarin-3-yl)-4-hydroxyquinolines. We present the results of a study of the effect of the synthesized compounds on thyroid function.

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Ukrainian Pharmaceutical Academy, Kharkhov 310002. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1100–1104, August, 1997.

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Ukrainets, I.V., Taran, S.G., Kodolova, O.L. et al. 4-Hydroxy-2-quinolones. 35. Synthesis and study of antithyroid properties of 1H-2-oxo-3-(coumarin-3-yl)-4-hydroxyquinolines. Chem Heterocycl Compd 33, 959–963 (1997). https://doi.org/10.1007/BF02253169

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  • DOI: https://doi.org/10.1007/BF02253169

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