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Azacycloalkanes

III. Tertiary α-azacycloalkyl carbinols. Synthesis and pharmacological activity

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Abstract

The synthesis of several tertiary alcohols containing a pyrrolidine or hexamethylenimine ring is described. The stimulating properties of these compounds compared with pyridrol are investigated. It was found that the pharmacological activity in this series is determined by the number of methylene groups in the aza ring system. The most active compound is the one containing the piperidine radical.

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Authors and Affiliations

  1. Institute of Pharmacology and Chemotherapy, Academy of Medical Sciences of the USSR, Moscow

    A. M. Likhosherstov, K. S. Raevskii, A. S. Lebedeva, A. M. Kritsyn & A. P. Skoldinov

Authors
  1. A. M. Likhosherstov
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  2. K. S. Raevskii
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  3. A. S. Lebedeva
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  4. A. M. Kritsyn
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  5. A. P. Skoldinov
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Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, No. 1, pp. 30–35, January, 1967.

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Likhosherstov, A.M., Raevskii, K.S., Lebedeva, A.S. et al. Azacycloalkanes. Pharm Chem J 1, 27–31 (1967). https://doi.org/10.1007/BF00768114

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  • DOI: https://doi.org/10.1007/BF00768114

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