Summary
Resolution of alkyn-3-ols has been achieved using a lipase from Candida rugosa to esterify the alcohols with trifluoroethyl butyrate in hexane to give the (S)-alcohols and the (R)-esters. Subsequent reacylation of the product alcohols and alcoholysis of the esters with 1-butanol furnished the (S)-alcohols with good (86–91% ees) and the (R)-butyrate with moderate enantiomeric purities (62–64% ees).
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Sharma, A., Sankaranarayanan, S. & Chattopadhyay, S. Enzymatic resolution of alkyn-3-ols in non-aqueous medium. Biotechnol Lett 18, 1391–1394 (1996). https://doi.org/10.1007/BF00129341
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DOI: https://doi.org/10.1007/BF00129341