Summary
The effects of ethanol on the growth rates of twoSaccharomyces yeast strains were measured during normal batch fermentative growth and compared with those measured by initial rate studies. In the light of previous work, which has highlighted the loss of cell replicative ability caused by ethanol, the results imply that the observed reduction in growth rate reflects a mixture of true inhibition and replicative inactivation.
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Ciftci, T., Constantinides, A. and Wang, S.S. (1983) Ann. New York Acad. Sci., 413, 157–167.
Ciftci, T., Wang, S.S. and Constantinides, A. (1981) Biotechnol. Bioeng., 23, 1407–1408.
Dasari, G., Roddick, R., Connor, M.A. and Pamment, N.B. (1983) Biotechnol. Lett., 5, 715–720.
Fulmer, E.I., (1921) J. Phys. Chem., 25, 10–18.
Ghose, T.K. and Tyagi, R.D. (1979) Biotechnol. Bioeng., 21, 1401–1420.
Hoppe, G.K. and Hansford, G.S. (1982) Biotechnol. Lett., 4, 39–44.
Hunt, W.A. (1975) in “Biochemical Pharmacology of Ethanol”, ed. E. Majchrowicz, Plenum Press, pp 195–206.
Jones, R.P. and Greenfield, P.F. (1984) Biotechnol. Lett., 6, 471–476.
Jones, R.P. and Greenfield, P.F. (1985) Biotechnol. Bioeng., submitted.
Leao, C. and van Uden, N. (1982) Biotechnol. Bioeng., 24, 2601–2604.
Leao, C. and van Uden, N. (1983) Biotechnol. Bioeng., 25, 2085–2090.
Lloyd, D., Poole, R.K. and Edwards, S.W. (editors) (1982) “The Cell Division Cycle”, Academic Press, NY.
Loureiro, V. and Ferreira, H.G. (1983) Biotechnol. Bioeng., 25, 2263–2269.
Nagodawithana, T.W. and Steinkraus, (1976) Appl. Environ. Microbiol., 31, 163–167.
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Jones, R.P., Greenfield, P.F. Replicative inactivation and metabolic inhibition in yeast ethanol fermentations. Biotechnol Lett 7, 223–228 (1985). https://doi.org/10.1007/BF01042367
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DOI: https://doi.org/10.1007/BF01042367