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Full matrix Analysis of Cross-relaxation Fails in Fractionally Deuterated Molecules

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Abstract

We have analyzed cross-relaxation in fractionally deuterated molecules and showed that the full matrix analysis fails except when the dilution is extreme. This is because the isotopic dilution alters the matrix exponential relationship between the observed spectrum and the cross-relaxation rate constants sought. Consequently, an average of the spectra of various isotopomers differs from the matrix exponential of an average relaxation matrix. We have derived a series expansion that allows the determination of the cross-relaxation rate constants in arbitrarily deuterated molecules.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Mayo Graduate School, Mayo Clinic and Mayo Foundation, Rochester, MN, 55905, U.S.A

    Zsolt Zolnai, Nenad Juranić & Slobodan Macura

Authors
  1. Zsolt Zolnai
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  2. Nenad Juranić
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  3. Slobodan Macura
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Zolnai, Z., Juranić, N. & Macura, S. Full matrix Analysis of Cross-relaxation Fails in Fractionally Deuterated Molecules. J Biomol NMR 12, 333–337 (1998). https://doi.org/10.1023/A:1008272628775

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  • DOI: https://doi.org/10.1023/A:1008272628775

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