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Preliminary evaluation in humans of Tc-99m-Q3, a new tracer for myocardial perfusion imaging

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Abstract

Trans[99m-Tc-acac2en(TMPP)2]+, where acac2en is N,N′-ethylenebis(acetylacetone iminate) and TMPP is tris-(3 methoxy propyl) phosphine, (shortened Q3) is a new lipophilic Technetium-99m-labelled compound developed for myocardial perfusion imaging. Encouraging data were obtained in the experimental animal. Aim of this study was to perform a preliminary evaluation of Q3 imaging in humans and to compare it with a reference coronary flow tracer such as Tc-99m microspheres.

Eight coronary artery disease patients (males, age 58.5±10 years) were studied. They were injected with 740 MBq of Q3 and single photon emission computed tomography (SPECT) was performed 90 minutes later. After 3 days 740 MBq of Tc-99m microspheres were injected through a pig-tail catheter in the left ventricle (LV), during heart catheterization, and SPECT was acquired 60 minutes later.

Q3 images showed a good target/background activity ratio: LV wall/LV cavity=4.16±1.2; myocardium/ lung=3.95±0.52; the related values with microspheres were 6.36±2.48 (N.S.) and 4.57±1.07 (N.S.), respectively. Q3 was cleared by the liver and at the moment of SPECT collection the myocardium/liver activity ratio was 1.54±0.32. The Q3 LV lateral wall/septum activity ratio showed a good correlation with the corresponding microspheres ratio: Q3 ratio=0.027 + 0.95 microspheres ratio, r=0.89, SEE=1.12, p<0.005.

In conclusion Q3 seems to have a potential value as myocardial perfusion tracer in humans, even if at present the labelling procedure is extremely laborious.

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Authors and Affiliations

  1. Department of Clinical Pathophysiology, Nuclear Medicine Unit, University of Florence, Viale Morgagni 85, I-50134, Florence, Italy

    G. Bisi, R. Sciagrà, L. Bacciottini, D. Antoniucci, G. M. Santoro, P. Buonamici & C. Bonino

  2. Department of Cardiology, Careggi Hospital, Florence

    D. Antoniucci, G. M. Santoro & P. Buonamici

  3. Sorin Biomedica, Saluggia, Italy

    C. Bonino

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  1. G. Bisi
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  2. R. Sciagrà
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  3. L. Bacciottini
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  4. D. Antoniucci
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  5. G. M. Santoro
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  6. P. Buonamici
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  7. C. Bonino
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Bisi, G., Sciagrà, R., Bacciottini, L. et al. Preliminary evaluation in humans of Tc-99m-Q3, a new tracer for myocardial perfusion imaging. Int J Cardiac Imag 9, 57–64 (1993). https://doi.org/10.1007/BF01142933

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