The distribution of heterochromatin in the chromosomes of the rat was determined by analysing two of its properties: late replication and differential stain with the DNA d-r method. The presence of late and non-late replicating c-heterochromatin in the genome of Rattus norvegicus indicates that this chromatin is an heterogeneous substance exhibiting different properties. Furthermore, the existence of heterochromatin formed by nonrepeated sequences or by sequences with a low degree of repetitiveness is suggested by the presence of late replicating areas which do not react with the DNA d-r method.
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Bianchi, N.O., Bianchi, M.S. & Vidal-Rioja, L. Heterochromatin and late replication in the chromosomes of the rat. Genetica 44, 513–519 (1973). https://doi.org/10.1007/BF00116807
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DOI: https://doi.org/10.1007/BF00116807