Skip to main content
SpringerLink
Log in

Pharmacological properties of a marine natural product, stypoldione, obtained from the brown alga Stypopodium zonale

  • Algae in Medicine and Pharmacology
  • Published:
Hydrobiologia Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Asnes, C. F. & L. Wilson, 1979. Isolation of bovine brain microtubule protein without glycerol: polymerization kinetics change during purification cycles. Analyt. Biochem. 98: 64–73.

    Google Scholar 

  • Farrell, K. W. & L. Wilson, 1980. Proposed mechanism for colchicine poisoning of microtubules reassembled in vitro from Strongylocentrotus purpuratus sperm tail outer doublet tubulin. Biochemistry 19: 3048–3054.

    Google Scholar 

  • Gaskin, F., C. R. Cantor & M. L. Shelanski, 1974. Turbidimetric studies of the in vitro assembly and disassembly of porcine neurotubules. J. mol. Biol. 89: 737–758.

    Google Scholar 

  • Gerwick, W. H. & W. Fenical, 1981. Ichthyotoxic and cytotoxic metabolites of the tropical brown alga Stypopodium zonale (Lamouroux) Papenfuss. J. org. Chem. 46: 22–27.

    Google Scholar 

  • Jacobs, R. S., S. White & L. Wilson, 1981. Selective compounds derived from marine organisms: effect on cell division in fertilized sea urchin eggs. Fed. Proc. 40: 26–29.

    Google Scholar 

  • Lambeir, A. & Y. Englesborghs, 1980. A quantitative analysis of tubulin-colchicine binding to microtubules. Eur. J. Biochem. 109: 619–624.

    Google Scholar 

  • Malawista, S. E., H. Sato & K. G. Bensch, 1968. Vinblastine and griseofulvin reversibly disrupt the living mitotic spindle. Science 160: 770–772.

    Google Scholar 

  • Margolis. R. L. & L. Wilson, 1977. Addition of colchicine-tubulin complex to microtubule ends: the mechanism of substoichiometric colchicine poisoning. Proc. Nat. Acad. Sci. (USA) 74: 3466–3470.

    Google Scholar 

  • Margolis, R. L., C. T. Rauch & L. Wilson, 1980. Mechanism of colchicine-dimer addition to microtubule ends: implications for the microtubule polymerization mechanism. Biochemistry 19: 5550–5557.

    Google Scholar 

  • O'Brien, E. T., R. S. Jacobs & L. Wilson, 1983. Inhibition of bovine brain microtubule assembly in vitro by stypoldione. Molecular Pharmacology (in press).

  • Olmsted, J. B. & G. G. Borisy, 1973. Characterization of microtubule assembly in porcine brain extracts by viscometry. Biochemistry 12: 4282–4289.

    Google Scholar 

  • Scatchard, G., 1949. The attraction of proteins for small molecules and ions. Ann. N.Y. Acad. Sci. 51: 660–672.

    Google Scholar 

  • Sternlicht, H. & I. Ringel, 1979. Colchicine inhibition of microtubule assembly via copolymer formation. J. Biol. Chem. 254: 10540–10555.

    Google Scholar 

  • Swann, M. M. & J. M. Mitchison, 1953. Cleavage of sea-urchin eggs in colchicine. J. Exp. Biol. 30: 506–514.

    Google Scholar 

  • White, S. & R. S. Jacobs, 1983. Effect of stypoldione on cell cycle progression, DNA and protein synthesis, and cell division in cultured sea urchin embryos. Molecular Pharmacology (in press).

  • Wilson, L., M. A. Jordon, A. Morse & R. L. Margolis, 1982. Interaction of vinblastine with steady-state microtubules in vitro. J. mol. Biol. 159: 125–149.

    Google Scholar 

  • Wilson, L., K. B. Snyder, W. C. Thompson & R. L. Margolis, 1982. A rapid filtration assay for analysis of microtubule assembly, disassembly, and steady state flux. In L. Wilson (ed.), Methods in Cell Biology, vol. 24, The Cytoskeleton, B. Academic Press, New York: 159–169.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biological Sciences and The Marine Science Institute, University of California, 93106, Santa Barbara, CA, U.S.A.

    E. Timothy O'Brien, Steven White, Robert S. Jacobs & Leslie Wilson

  2. The Eli Lilly Research Laboratories, 46285, Indianapolis, IN, U.S.A.

    George B. Boder

Authors
  1. E. Timothy O'Brien
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Steven White
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Robert S. Jacobs
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. George B. Boder
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Leslie Wilson
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

O'Brien, E.T., White, S., Jacobs, R.S. et al. Pharmacological properties of a marine natural product, stypoldione, obtained from the brown alga Stypopodium zonale . Hydrobiologia 116, 141–145 (1984). https://doi.org/10.1007/BF00027652

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00027652

Keywords

Search

Navigation