Abstract
Fresh samples of heparinized human blood from 10 healthy nonsmoking volunteers were used to study the effect of the inhaled anesthetic sevoflurane on the oxygen half-saturation pressure of hemoglobin (P50) and on polarographic measurements of oxygen tension at low values. Control samples had a baseline P50 of 26.9±0.2 mm Hg. When the blood samples were exposed to 1.75% (1 minimum alveolar concentration, MAC), 2.75%, and 3.5% (2 MAC) of sevoflurane, the P50 values were 27.0±0.5 mm Hg, 27.1±0.4 mm Hg, and 26.9±0.5 mm Hg, respectively. Our present data show that 1 to 2 MAC sevoflurane has no significant effect on P50 (P>0.05). Our data also show that sevoflurane did not interfere with polarographic measurements of oxygen tension (P>0.05). Other inhaled agents—halothane, enflurane, and isoflurane—do interfere with these measurements, and we cannot explain the difference.
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Kambam, J.R., Horton, B.F., Parris, W.C.V. et al. Effect of sevoflurane on P50 and on measurement of oxygen tension. J Clin Monitor Comput 4, 261–263 (1988). https://doi.org/10.1007/BF01617323
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DOI: https://doi.org/10.1007/BF01617323