Skip to main content
SpringerLink
Log in

Biomedical neutron research at the Californium User Facility for Neutron Science

  • Applications of Radioanalytical Methods to Biological and Clinical Systems
  • Published:
Journal of Radioanalytical and Nuclear Chemistry Aims and scope Submit manuscript

Abstract

The Californium User Facility for Neutron Science has been established at Oak Ridge National Laboratory (ORNL). The Californium Use Facility (CUF) is a part of the larger Californium Facility, which fabricates and stores compact252Cf neutron sources for worldwide distribution. The CUF can provide a cost-effective option for research with252Cf sources. Three projects at the CUF that demonstrate the versatility of252Cf for biological and biomedical neutron-based research are described: future establishment of a252Cf-based neutron activation analysis system, ongoing work to produce miniature high-intensity, remotely afterloaded252Cf sources for tumors therapy, and a recent experiment that irradiated living human lung cancer cells impregnated with experimental boron compounds to test their effectiveness for boron neutron capture therapy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. J. B. Knauer, R. C. Martin, Californium-252: Isotope for 21st Century Radiotherapy. in:J. G. Wierzbicki (Ed.), Kluwer Academic Publishers, Dordrecht. Netherlands, 1997, p. 7.

    Google Scholar 

  2. I. W. Osborne-Lee, C. W. Alexander, Californium-252: A Remarkable Versatile Radioisotope, ORNL/TM-12706, Oak Ridge National Laboratory, Oak Ridge, Tenn., 1995.

    Google Scholar 

  3. S. Reucroft, R. Rusack, D. Ruuska, J. Swain, Neutron Irradiation of APDs Using252Cf, NUB-3132, Northeastern University, Boston, Mass., 1996.

    Google Scholar 

  4. Y. Maruyama, J. R. Van Nagell J. Yoneda, E. S. Donaldson, H. H. Gallion, D. Powell, R. J. Kryscio, Cancer, 68 (1991) 1189.

    CAS  Google Scholar 

  5. W. C. Mosley, P. K. Smith, P. E. McBeath. Palladium-252Cf Oxide Cermet. An Improved Form for252Cf Sources, DP-MS-72-4. Savannah River Laboratory, Aiken, S.C., 1972.

    Google Scholar 

  6. T. E. Byrne, In Vitro Determination of Uptake and Biological Efficacy of Boronated Compounds for Neutron Capture Therapy in the Human Lung Cancer Cell Line A549, The University of Tennessee, Knoxville, Dissertation, 1996.

    Google Scholar 

  7. T. E. Byrne, L. F. Miller, R. Martin, D. Duckworth, M. Terzaghi-Howe, G. W. Kabalka, Determination of Uptake and Efficacy of Compounds for Boron Neutron Capture Therapy, presented at the Health Physics Society Annual Meeting, San Antonio, Texas June 29–July 3, 1997.

Download references

Author information

Authors and Affiliations

  1. Chemical Technology Division, Oak Ridge National Laboratory, 3781-6385, Oak Ridge, TN, USA

    R. C. Martin

  2. Biology Department, Roane State Community College, 37748, Harriman, TN, USA

    T. E. Byrne

  3. Department of Nuclear Engineering, The University of Tennessee, 37996, Knoxville, TN, USA

    L. F. Miller

Authors
  1. R. C. Martin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. E. Byrne
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. L. F. Miller
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Martin, R.C., Byrne, T.E. & Miller, L.F. Biomedical neutron research at the Californium User Facility for Neutron Science. J Radioanal Nucl Chem 236, 5–11 (1998). https://doi.org/10.1007/BF02386308

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02386308

Keywords

Search

Navigation