Abstract
Monoclonal antibody ior egf/r3 is a IgG2a, recognizes the epidermal growth factor receptor. The aim of the present work was to evaluate the diagnostic efficacy of the99mTc-labeled ior egf/r3 for the detection of epithelial tumors, its metastasis and its recurrences. The sensitivity by organs was: brain 100%, diegestive tract 90%, head and neck 89%, lung 84% and breast 79%. The overall sensitivity, specificity, accuracy, positive predictive value and negative predictive value of the immunoscintigraphic imaging were 84.1%, 100%, 86.5%, 100% and 52.4%, respectively. Immunoscintigraphy with99mTc-ior egf/r3 is useful for the diagnosis and follow-up of epithelial tumors.
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Suzarte, M.R., Rodríguez, N., Oliva, J.P. et al. ior egf/r3: A murine monoclonal antibody for diagnostic of epithelial tumors. J Radioanal Nucl Chem 240, 499–503 (1999). https://doi.org/10.1007/BF02349402
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DOI: https://doi.org/10.1007/BF02349402