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Soluble analogs of GalCer and suramin as potential inhibitors of HIV-1 infection: Key role of self-association

  • Part VII. Inhibition Of HIV Entry Into CD4− Cells
  • Published:
Perspectives in Drug Discovery and Design

Summary

Lesions observed in the brain and intestine of HIV-infected individuals may stem from a direct infection of CD4−/GalCer+ cells by the virus within these two organs. HIV-infection of such cells may also facilitate entry of the virus through the intestinal mucosa. Apart from treatment with conventional anti-viral agents, the use of drugs that block interactions between the virus and CD4−/GalCer+ cells represents a promising therapeutic strategy in the fight against AIDS. We present here two families of compounds with such activity, namely soluble analogs of GalCer and a family of suramin analogs. The role of self-association is discussed.

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Authors and Affiliations

  1. Laboratoire des IMRCP, CNRS URA 470, Université Paul Sabatier, 118 Route de Narbonne, F-31062, Toulouse Cédex, France

    Brigitte Guidetti, Christiane André-Barrès, Isabelle Rico-Lattes & Armand Lattes

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  1. Brigitte Guidetti
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  2. Christiane André-Barrès
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  3. Isabelle Rico-Lattes
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  4. Armand Lattes
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Guidetti, B., André-Barrès, C., Rico-Lattes, I. et al. Soluble analogs of GalCer and suramin as potential inhibitors of HIV-1 infection: Key role of self-association. Perspectives in Drug Discovery and Design 5, 234–242 (1996). https://doi.org/10.1007/BF02174018

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  • DOI: https://doi.org/10.1007/BF02174018

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