Abstract
Specimens from 30 cases of benign prostatichyperplasia and 75 cases of prostatic carcinomaobtained during suprapubic prostatectomy, transurethalresection of the prostate and radical prostatectomy,were stained immunohistochemically for S-100 protein,prostatic acid phosphatase (PAP), prostatic specificantigen (PSA), neuron specific enolase (NSE) andpolyclonal keratin. S-100 protein was positive in9.3% of prostatic carcinomas and negative in allcases of prostatic hyperplasia. PAP and PSA werepositive in all cases, while NSE was positive in 16%of the carcinoma cases. Polyclonal keratin waspositive in both cell layers of the double layeredhyperplastic prostatic epithelium with a more intensestaining pattern in the outer cell layer. The authorsbelieve that the S-100 protein immunoreactivityobserved in some prostatic carcinomas, reflecting thechange in the functional status of the neoplasticcells, might be of prognostic significance. They alsoemphasize the non-myoepithelial nature of the outercell layer of the double layered prostaticepithelium.
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References
Benda P, Lightbody J, Sato G, Levine L, Sweet W. Differentiated rat glial cell stain in tissue culture. Science 1968; 161: 370–371.
Moore BW. A soluble protein characteristic of the nervous system. Biochem Biophys Res Commun 1965; 19: 739–744.
Kahn HJ, Marks A, Heather T, Reuben B. Role of antibody to S-100 protein in diagnostic pathology. Am J Clin Pathol 1983; 79: 341–347.
Vanstapel MJ, Gatter KC, De Wolf-Peeters Ch, Mason DY, Desmet VD. New sites of human S-100 immunoreactivity detected with monoclonal antibodies. Am J Clin Pathol 1986; 85: 160–168.
Howat AJ, Mills PM, Lyon TJ, Stephenson TJ. Absence of S-100 prostatic glands. Brief report. Histopathology 1988; 13: 468–470.
Grignon DJ, Ro JY, Srigley JR, Troncoso P, Raymond AK, Ayale AG. Sclerosing adenosis of the prostate gland: a lesion showing myoepithelial differentiation. Am J Surg Pathol 1992; 16: 383–391.
Sakamoto N, Tsuneyoshi M, Eujoji M. Sclerosing adenosis of the prostate: Histopathologic and immunohistochemical studies. Am J Surg Pathol 1992; 15: 660–667.
Taylor R, Chur B. Immunoperoxidase Techniques. Arch Pathol Lab Med 1978; 102: 113–121.
Kazzaz BA. Argentaffin and argyrophil cells in the prostate. J Pathol 1974; 112: 189–197.
Di Sant’ Agnese PA, De Mesy Jensen KL, Churkian CV. Human prostate endocrine-paracrine (APUD) cells: Distributional analysis with a comparison of serotonin and neuron specific enolase immunoreactivity and silver stains. Arch Pathol Lab Med 1985; 109: 607–612.
Fetissof F, Dubois MP, Arbeille-Brassart B, Lanson Y, Boivin F, Jobart P. Endocrine cells in the prostate gland, urothelium and Brenner tumors. Immunohistological and ultrastructural studies. Virchows Arch (Cell Pathol) 1983; 42: 53–64.
DeLellis RA, Tischler AS, Wolfe HJ. Multidirectional differentiation in neuroendocrine neoplasms. J Histochem Cytochem 1984; 32: 899.
Di Sant’ Agnese PA, De Mesy Jensen KL. Neuroendocrine differentiation in Prostatic Carcinoma. Hum Pathol 1987; 18: 849–856.
Egan MJ, Newman J, Crocker J, Collard M. Immunohistochemical localisation of S-100 protein in benign and malignant conditions of the breast. Arch Pathol Lab Med 1987; 111: 28–31.
Fisher ER, Sieracki JC. Ultrastructure of human normal and neoplastic prostate. Pathol Annu 1970; 5: 1–26.
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Constantinides, C., Manousakas, T., Pavlaki, K. et al. The distribution of S-100 protein in hyperplastic and neoplastic prostatic epithelium. Int Urol Nephrol 32, 259–261 (2000). https://doi.org/10.1023/A:1007118210759
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DOI: https://doi.org/10.1023/A:1007118210759