Abstract
The disposition and dosage regimen of cephaloridine were investigated in healthy calves following a single intramuscular administration of 10 mg/kg. The absorption halflife, climination halflife, apparent volume of distribution and total body clearance were 0.107±0.025 h, 2.08±0.14 h, 0.70±0.07L kg-1 and 235.8±21.9 ml kg-1 h-1, respectively. Therapeutic plasma levels (≥1 μg/ml) were maintained for up to 7 h. A satisfactory intramuscular dosage regimen for cephaloridine in calves would be 10 mg/kg repeated at 8 h intervals.
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Chaudhary, R.K., Srivastava, A.K. Disposition and dosage regimen of cephaloridine in calves. Vet Res Commun 13, 325–329 (1989). https://doi.org/10.1007/BF00420839
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DOI: https://doi.org/10.1007/BF00420839