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Pharmacokinetics and dosing regimen of aminosidine in the dog

  • Pharmacology
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Abstract

The kinetic behaviour of the aminoglycoside aminosidine, given at 15 mg/kg intravenously, intramuscularly and subcutaneously, was studied in 5 dogs to determine the appropriate dosage schedule. The pharmacokinetic behaviour of aminosidine in dogs was similar to that in other species, except that it was eliminated more slowly (β=0.007±0.0003 min-1). Intramuscular and subcutaneous administration produced peak serum concentrations (C max[im]=32±6.4 μg/ml; C max[sc]=36±3.4 μ/ml) and times to peak concentration (T max=60 min for both) that did not differ significantly; and neither compartmental nor non-compartmental analysis revealed any significant differences between any of the kinetic parameters obtained for these two extravenous routes of administration. Comparison of these results with previously published data suggests that aminosidine given once daily at 15 mg/kg would be as effective as, and safer than, the two or three daily administrations commonly employed in dogs.

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Abbreviations

ALAT:

alanine aminotransferase

ASAT:

aspartate aminotransferase

AUC:

area under the curve

BUN:

blood urea nitrogen

Clb :

body clearance

C max :

peak plasma concentration

CV:

coefficient of variation

i.m.:

intramuscular(ly)

i.v.:

intravenous(ly)

LDH:

lactate dehydrogenase

MIC:

minimal inhibitory concentration

MRT:

mean residence time

PAE:

post-antibiotic effect

PCV:

packed cell volume

RBC:

red blood cell count

s.c.:

subcutaneous(ly)

SD:

standard deviation

WBC:

white blood cell count

V d(ss) :

distribution volume at steady state

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Authors and Affiliations

  1. Institute of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Milan, Via Celoria 10, 20133, Milan, Italy

    C. Belloli, S. Carli, R. Villa & O. Sonzogni

  2. Institute of Veterinary Pharmacology and Toxicology, University of Bari, Bari, Italy

    G. Crescenzo & P. Ormas

  3. Institute of Veterinary Clinical Medicine, Faculty of Veterinary Medicine, University of Bari, Bari, Italy

    G. Carelli

Authors
  1. C. Belloli
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  2. G. Crescenzo
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  3. S. Carli
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  4. R. Villa
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  5. O. Sonzogni
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  6. G. Carelli
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  7. P. Ormas
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Belloli, C., Crescenzo, G., Carli, S. et al. Pharmacokinetics and dosing regimen of aminosidine in the dog. Veterinary Research Communications 20, 533–541 (1996). https://doi.org/10.1007/BF00396296

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