Abstract
Concentrations of albendazole sulphoxide and its sulphone metabolite in plasma in cattle and buffalo were measured by high-performance liquid chromatography after single and divided intraruminal administration of albendazole at the recommended nematocidal and fasciolicidal dose rates of 7.5 and 15.0 mg/kg body weight, respectively. No significant differences in the plasma concentrations of the metabolites or their pharmacokinetic parameters were observed between cattle or buffalo at either dose rate. Pharmacokinetic analysis and the disposition curve of the metabolites indicated increased uptake of the drug in both cattle and buffalo when the same total amount of the drug was given in divided doses compared to a single dose (p<0.05). The divided dose schedules of administration could possibly be exploited to extend the life of the available benzimidazole anthelmintics.
Similar content being viewed by others
REFERENCES
Gyurik, R.J., Chow, A.W., Zaber, B., Brunner, E.L., Miller, J.A., Villani, A.J., Petka, L.A. and Parish, R.C., 1981. Metabolism of albendazole in cattle, sheep, rats and mice. Drug Metabolism and Disposition, 9, 503-508
Hennessy, D.R., 1994. The disposition of antiparasitic drugs in relation to the development of resistance by parasites of livestock. Acta Tropica, 56, 125-141
Hennessy, D.R., 1997. Physiology, pharmacology and parasitology. International Journal for Parasitology, 27, 145-152
Hennessy, D.R., Sangster, N.C., Steel, J.W. and Colins, G.H., 1987. Comparative pharmacokinetic behaviour of albendazole in sheep and goats. International Journal for Parasitology, 23, 321-325
Hennessy, D.R., Steel, J.W., Lacey, E., Eagleson, G.K. and Prichard, R.K., 1989. The disposition of albendazole in sheep. Journal of Veterinary Pharmacology and Therapeutics, 8, 270-275
Prichard, R.K., Hennessy, D.R. and Steel, J.W., 1978. Prolonged administration: a new concept for increasing spectrum and effectiveness of anthelmintics. Veterinary Parasitology, 4, 309-315
Prichard, R.K., Hennessy, D.R., Steel, J.W. and Lacey, E., 1985. Metabolic concentrations in plasma following treatment of cattle with five anthelmintics. Research in Veterinary Science, 39, 173-178
Sanyal, P.K., 1993. Plasma levels of fenbendazole metabolites in buffalo and cattle after long-term intraruminal administration. Veterinary Quarterly, 15, 157-159
Sanyal, P.K., 1994. The pharmacokinetic behaviour of fenbendazole in cattle and buffalo. Journal of Veterinary Pharmacology and Therapeut, 17, 1-4
Sanyal, P.K., 1995. Kinetic disposition of triclabendazole in buffalo compared to cattle. Journal of Veterinary Pharmacology and Therapeutics 18, 370-374
Sanyal, P.K., 1997. Disposition kinetics of albendazole in buffalo and cattle. Journal of Veterinary Pharmacology and Therapeutics, 20, 240-242
Theodorides, V.J., Gyurik, R.J., Kingsbury, W.D. and Parish, R.C., 1976. Anthelmintic activity of albendazole against liver flukes, tapeworms, lung and gastrointestinal round worms. Experientia, 32, 702-703
Yadav, C.L. and Uppal, R.P., 1996. Evidence of fenbendazole resistance in cattle parasites. Proceedings of VIIIth National Congress of Veterinary Parasitology, Hisar, Haryana, October 1996, 78
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sanyal, P. The disposition kinetics of albendazole following the administration of single and divided doses to cattle and buffalo. Vet Res Commun 22, 87–96 (1998). https://doi.org/10.1023/A:1006023328617
Issue Date:
DOI: https://doi.org/10.1023/A:1006023328617