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Lack of mutagenicity of fasciolicides

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Abstract

Six fasciolicides, bithionol, bromofenofos, DS-6, nitroxynil, oxyclozanide and tribromsalan, were tested for mutagenicity in theSalmonella reverse mutation test usingS.typhimurium tester strains TA100, TA98, TA153, TA1537 and TA1538 and the micronucleus test in mice. None of the fasciolicides increased the number of revertant colonies in any tester strain in the presence and absence of S9 mix, nor did they induce a significant increase of the micronuclei in erythrocytes. Taking the high correlation between mutagenicity and carcinogenicity into consideration, these results suggest that the fasciolicides tested in this investigation are devoid of carcinogenic action.

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Authors and Affiliations

  1. National Veterinary Assay Laboratory, 1-15-1 Tokura, Kokubunji-shi, 185, Tokyo, (Japan)

    H. Yoshimura, M. Nakamura & T. Koeda

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  1. H. Yoshimura
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  2. M. Nakamura
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  3. T. Koeda
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Yoshimura, H., Nakamura, M. & Koeda, T. Lack of mutagenicity of fasciolicides. Vet Res Commun 9, 147–152 (1985). https://doi.org/10.1007/BF02215138

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  • DOI: https://doi.org/10.1007/BF02215138

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